Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning.

Journal: Biology direct
PMID: 39881407

Abstract

BACKGROUND: Carotid atherosclerotic plaque is the primary cause of cardiovascular and cerebrovascular diseases. It is closely related to oxidative stress and immune inflammation. This bioinformatic study was conducted to identify key oxidative stress-related genes and key immune cell infiltration involved in the formation, progression, and stabilization of plaques and investigate the relationship between them.

Authors

  • Yiqin Yang
    The Second School of Clinical Medicine, Shandong University, Jinan, China.
  • Mei Dong
    Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Forensic Identification Center of Hebei Medical University, College of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China.

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