Alzheimer's disease: an integrative bioinformatics and machine learning analysis reveals glutamine metabolism-associated gene biomarkers.

Journal: BMC pharmacology & toxicology
Published Date: Jan 28, 2025

Abstract

BACKGROUND: Alzheimer's disease (AD), a hallmark of age-related cognitive decline, is defined by its unique neuropathology. Metabolic dysregulation, particularly involving glutamine (Gln) metabolism, has emerged as a critical but underexplored aspect of AD pathophysiology, representing a significant gap in our current understanding of the disease.

Authors

  • Naifei Xing
    Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, 264100, PR China.
  • Jingwei Yan
    Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, 264100, PR China.
  • Rong Gao
    School of Computer Science, Hubei University of Technology, Wuhan 430068, China.
  • Aihua Zhang
    College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
  • Huiyan He
    Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, 264100, PR China.
  • Man Zheng
    Dongying People's Hospital (Dongying Hospital of Shandong Provincial Hospital Group), Dongying, 257091, Shandong, People's Republic of China.
  • Guojing Li
    Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, 264100, PR China. 15166389542@163.com.

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