Non-invasive Assessment of Human Epidermal Growth Factor Receptor 2 Expression in Gastric Cancer Based on Deep Learning: A Computed Tomography-based Multicenter Study.

Journal: Academic radiology
PMID: 39870563

Abstract

RATIONALE AND OBJECTIVES: The expression of human epidermal growth factor receptor 2 (HER2) in gastric cancer is closely associated with its treatment outcomes and prognosis. This study aims to develop and validate a HER2 prediction model based on computed tomography (CT). Additionally, the study evaluates the robustness of the proposed model.

Authors

  • Zhong-Hui Wu
    Department of Radiology, Xinhua Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China (Z.H.W., Y.Q.M., X.Y.W., N.X.Y., X.Y.W., G.R.); Shanghai Medical College, Fudan University, Shanghai 200032, China (Z.H.W., X.R.R., Y.Q.M.).
  • Xiao-Rong Ren
    Shanghai Medical College, Fudan University, Shanghai 200032, China (Z.H.W., X.R.R., Y.Q.M.).
  • Yu-Qi Meng
    Department of Thoracic Surgery, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College, Lanzhou, Gansu, China.
  • Xin-Yun Wang
    Department of Radiology, Xinhua Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China (Z.H.W., Y.Q.M., X.Y.W., N.X.Y., X.Y.W., G.R.).
  • Ning-Xin Yang
    Department of Radiology, Xinhua Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China (Z.H.W., Y.Q.M., X.Y.W., N.X.Y., X.Y.W., G.R.).
  • Xiao-Yu Wang
    Department of Radiology, Xinhua Hospital, Shanghai Jiaotong University Medical School, Shanghai 200092, China (Z.H.W., Y.Q.M., X.Y.W., N.X.Y., X.Y.W., G.R.).
  • Gang Ren
    Department of Surgery, The University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.

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