Assessment of glymphatic function and white matter integrity in children with autism using multi-parametric MRI and machine learning.

Journal: European radiology
PMID:

Abstract

OBJECTIVES: To assess glymphatic function and white matter integrity in children with autism spectrum disorder (ASD) using multi-parametric MRI, combined with machine learning to evaluate ASD detection performance.

Authors

  • Miaoyan Wang
    Department of Radiology, Affiliated Children's Hospital of Jiangnan University, Wuxi, China.
  • Keyi He
    School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Lili Zhang
    Pharmaceutics Department, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, PR China.
  • Dandan Xu
    The Graduate Institude of Design Science, Tatung University, 40, Sec. 3, Zhongshan N. Rd., Taipei 104, Taiwan. Electronic address: d10717014@ms.ttu.edu.tw.
  • Xianjun Li
    Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address: xianj.li@mail.xjtu.edu.cn.
  • Lei Wang
    Department of Nursing, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Bo Peng
    Institute for Environmental and Climate Research, Jinan University, Guangzhou, China.
  • Anqi Qiu
    Department of Biomedical Engineering and Clinical Research Center, National University of Singapore, Singapore. Electronic address: bieqa@nus.edu.sg.
  • Yakang Dai
    Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu 215163, China. Electronic address: daiyk@sibet.ac.cn.
  • Cailei Zhao
    Department of Radiology (C.Z., H.Z.), Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
  • Haoxiang Jiang
    Department of Radiology, Affiliated Children's Hospital of Jiangnan University, Wuxi, China. jianghaoxiang@jiangnan.edu.cn.