Development and validation of machine-learning models for predicting the risk of hypertriglyceridemia in critically ill patients receiving propofol sedation using retrospective data: a protocol.

Journal: BMJ open
PMID:

Abstract

INTRODUCTION: Propofol is a widely used sedative-hypnotic agent for critically ill patients requiring invasive mechanical ventilation (IMV). Despite its clinical benefits, propofol is associated with increased risks of hypertriglyceridemia. Early identification of patients at risk for propofol-associated hypertriglyceridemia is crucial for optimising sedation strategies and preventing adverse outcomes. Machine-learning (ML) models offer a promising approach for predicting individualised patient risks of propofol-associated hypertriglyceridemia.

Authors

  • Jiawen Deng
    Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Kiyan Heybati
    Mayo Clinic Alix School of Medicine (Jacksonville), Mayo Clinic, Jacksonville, FL, USA.
  • Hemang Yadav
    Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, Minnesota, USA Yadav.Hemang@mayo.edu.