An Artificial Intelligence-Digital Pathology Algorithm Predicts Survival After Radical Prostatectomy From the Prostate, Lung, Colorectal, and Ovarian Cancer Trial.

Journal: The Journal of urology
PMID:

Abstract

PURPOSE: Clinical variables alone have limited ability to determine which patients will have recurrence after radical prostatectomy (RP). We evaluated the ability of locked multimodal artificial intelligence (MMAI) algorithms trained on prostate biopsy specimens to predict prostate cancer-specific mortality (PCSM) and overall survival (OS) among patients undergoing RP with digitized RP specimens.

Authors

  • Eric V Li
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Yi Ren
    Institute for Advanced Study, Shenzhen University, Shenzhen, 518060, P. R. China.
  • Jacqueline Griffin
    Artera Inc, Los Altos, CA.
  • Jialin Han
    Artera, Inc, Los Altos, California.
  • Rikiya Yamashita
    Artera, Inc., Los Altos, CA.
  • Akinori Mitani
    Artera, Inc., Los Altos, CA.
  • Ruoji Zhou
    Department of Pathology, University of California, Los Angeles, Los Angeles, California.
  • Huei-Chung Huang
    Artera, Inc., Los Altos, CA.
  • Ximing Yang
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Felix Y Feng
    Department of Radiation Oncology, University of California, San Francisco, San Francisco.
  • Andre Esteva
    Artera, Inc., Los Altos, CA.
  • Hiten D Patel
    The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Edward M Schaeffer
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago.
  • Lee A D Cooper
    Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, 30322, USA. lee.cooper@emory.edu.
  • Ashley E Ross
    University of Cincinnati, Department of Chemistry, 312 College Drive, 404 Crosley Tower, Cincinnati, Ohio 45221-0172, United States.