Bacteria Flagella-Mimicking Polymer Multilayer Magnetic Microrobots.

Journal: Small methods
PMID: 39838737

Abstract

Mass production of biomedical microrobots demands expensive and complex preparation techniques and versatile biocompatible materials. Learning from natural bacteria flagella, the study demonstrates a magnetic polymer multilayer cylindrical microrobot that bestows the controllable propulsion upon an external rotating magnetic field with uniform intensity. The magnetic microrobots are constructed by template-assisted layer-by-layer technique and subsequent functionalization of magnetic particles onto the large opening of the microrobots. Geometric variables of the polymer microrobots, such as the diameter and wall thickness, can be controlled by selection of porous template and layers of assembly. The microrobots perform controllable propulsion through the manipulation of magnetic field. The comparative analysis of the movement behavior reveals that the deformation of microrobots may be attributed to the propulsion upon rotating magnetic field, which is similar to that of natural bacteria. The influence of actuation and frequency on the velocity of the microrobots is studied. Such polymer multilayer magnetic microrobots may provide a novel concept to develop rapidly delivering drug therapeutic agents for diverse practical biomedical uses.

Authors

  • Liang Lu
    Department of Pathology & Immunology, Washington University in St. Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8118, Saint Louis, MO, 63110, United States.
  • Shuang Bai
    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
  • Jiaqi Shi
    College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
  • Hutao Zhang
    The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, 150001, China.
  • Gang Hou
    National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, 100029, China.
  • Wei Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
  • Shoubin Sun
    The Fourth Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, 150001, China.
  • Tianyun Huang
    State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150006, China.
  • Yuxin Jia
    Department of Mathematics, Imperial College London, London, SW7 2AZ, UK.
  • Alexander Granovsky
    Magnetism Department, Faculty of Physics, Lomonosov Moscow State University, Moscow, 119991, Russia.
  • Perov Nikolai
    Magnetism Department, Faculty of Physics, Lomonosov Moscow State University, Moscow, 119991, Russia.
  • Zhiguang Wu
    Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), Harbin Institute of Technology, Harbin 150001, China. zhiguangwu@hit.edu.cn qianghe@hit.edu.cn.
  • Hui Xie
    Department of Breast Diseases, The First Affiliated Hospital of Nanjing Medical University & Jiangsu Province Hospital, Nanjing, Jiangsu, China.
  • He Wu
    School of Economics, Jilin University, Changchun 130000, Jilin, China.

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