Integrative machine learning frameworks to uncover specific protein signature in neuroendocrine cervical carcinoma.

Journal: BMC cancer
PMID:

Abstract

OBJECTIVE: Neuroendocrine cervical carcinoma (NECC) is a rare but highly aggressive tumor. The clinical management of NECC follows neuroendocrine neoplasms and cervical cancer in general. However, the diagnosis and prognosis of NECC remain dismal. The aim of this study was to identify a specific protein signature for the diagnosis of NECC.

Authors

  • Tao Shen
    Shanghai Chenpon Pharmaceutical Co., Ltd., Shanghai, China.
  • Tingting Dong
    Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Metabolic Diseases, Anhui Provincial Engineering Research Centre for Molecular Detection and Diagnostics, College of Life Sciences, Anhui Normal University, Wuhu, China.
  • Haiyang Wang
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing Cancer Hospital & Institute, Beijing, China.
  • Yi Ding
    Clinical and Research Center of AIDS, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Jianuo Zhang
    Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Metabolic Diseases, Anhui Provincial Engineering Research Centre for Molecular Detection and Diagnostics, College of Life Sciences, Anhui Normal University, Wuhu, China.
  • Xinyi Zhu
    Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
  • Yeping Ding
    Department of Gynecology, East China Normal University Wuhu Affiliated Hospital (The Second People's Hospital of Wuhu City), Wuhu, 241000, China.
  • Wen Cai
    Department of Gynecology, East China Normal University Wuhu Affiliated Hospital (The Second People's Hospital of Wuhu City), Wuhu, 241000, China.
  • Yalan Wei
    Department of Gynecology, East China Normal University Wuhu Affiliated Hospital (The Second People's Hospital of Wuhu City), Wuhu, 241000, China.
  • Qiao Wang
    Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang R & D Centre for Food Technology and Equipment, Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, China; Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, Zhejiang, China.
  • Sufen Wang
    Department of Pathology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, China. Wangsufen0808@163.com.
  • Feiyun Jiang
    Department of Gynecology, East China Normal University Wuhu Affiliated Hospital (The Second People's Hospital of Wuhu City), Wuhu, 241000, China. Fyjiang6872@163.com.
  • Bin Tang
    Basic Medical College , Southwest Medical University , Luzhou , Sichuan , China.