Assessing Algorithmic Fairness With a Multimodal Artificial Intelligence Model in Men of African and Non-African Origin on NRG Oncology Prostate Cancer Phase III Trials.

Journal: JCO clinical cancer informatics
PMID: 40344545

Abstract

PURPOSE: Artificial intelligence (AI) tools could improve clinical decision making or exacerbate inequities because of bias. African American (AA) men reportedly have a worse prognosis for prostate cancer (PCa) and are underrepresented in the development genomic biomarkers. We assess the generalizability of tools developed using a multimodal AI (MMAI) deep learning system using digital histopathology and clinical data from NRG/Radiation Therapy Oncology Group PCa trials across racial subgroups.

Authors

  • Mack Roach
    Department of Radiation Oncology, University of California at San Francisco, San Francisco, California; Department of Urology, University of California at San Francisco, San Francisco, California.
  • Jingbin Zhang
    Artera, Inc., Los Altos, CA.
  • Osama Mohamad
    Department of Radiation Oncology, University of California, San Francisco, San Francisco.
  • Douwe van der Wal
    Artera, Inc., Los Altos, CA.
  • Jeffry P Simko
    Department of Radiation Oncology, University of California, San Francisco, San Francisco.
  • Sandy DeVries
    NRG Oncology Biospecimen Bank, University of California, San Francisco, San Francisco.
  • Huei-Chung Huang
    Artera, Inc., Los Altos, CA.
  • Songwan Joun
    Artera, Santa Barbara, CA.
  • Edward M Schaeffer
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago.
  • Todd M Morgan
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI.
  • Jessica Keim-Malpass
    Artera, Santa Barbara, CA.
  • Emmalyn Chen
    Artera, Inc., Los Altos, CA.
  • Rikiya Yamashita
    Artera, Inc., Los Altos, CA.
  • Jedidiah M Monson
    Department of Radiation Oncology, Saint Agnes Medical Center, Fresno, CA.
  • Farah Naz
    Horizon Health Network-Saint John Regional Hospital, Saint John, NB.
  • James Wallace
    University of Chicago Medicine Medical Group, Chicago.
  • Jean-Paul Bahary
    Department of Radiation Oncology, Centre Hospitalier de l'Universite de Montreal, Montreal.
  • Derek Wilke
    Nova Scotia Cancer Centre/Nova Scotia Health/QEII Health Sciences Centre, Halifax, NS.
  • Sonny Batra
    VA Boston Healthcare System, Boston, MA.
  • Gregory B Biedermann
    University of Missouri-Ellis Fischel, Columbia, MO.
  • Sergio Faria
    The Research Institute of the McGill University Health Centre (MUHC), Montreal, QC.
  • Lindsay Hwang
    Keck School of Medicine of USC, Los Angeles, CA.
  • Howard M Sandler
    Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Daniel E Spratt
    Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland.
  • Stephanie L Pugh
    NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania.
  • Andre Esteva
    Artera, Inc., Los Altos, CA.
  • Phuoc T Tran
    Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore.
  • Felix Y Feng
    Department of Radiation Oncology, University of California, San Francisco, San Francisco.

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