AIMC Topic: Clinical Trials, Phase III as Topic

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Discovery of mutations predictive of survival benefit from immunotherapy in first-line NSCLC: A retrospective machine learning study of IMpower150 liquid biopsy data.

Computers in biology and medicine Mar 4, 2025
Predictive biomarker identification in cancer treatment has traditionally relied on pre-defined analyses, limiting discoveries to expected biomarkers and potentially overlooking novel ones predictive of therapy response. In this work, we develop a no...
Male Middle Aged Lung Neoplasms Immunotherapy Retrospective Studies Female Humans Aged Machine Learning Biomarkers, Tumor Paclitaxel Liquid Biopsy Clinical Trials, Phase III as Topic Bevacizumab Antineoplastic Combined Chemotherapy Protocols Carcinoma, Non-Small-Cell Lung Randomized Controlled Trials as Topic Mutation
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Meta-analysis of Individual Patient-level Data for a Multimodal Artificial Intelligence Biomarker in High-risk Prostate Cancer: Results from Six NRG/RTOG Phase 3 Randomized Trials.

European urology Jul 17, 2024
Humans Artificial Intelligence Randomized Controlled Trials as Topic Prostatic Neoplasms Clinical Trials, Phase III as Topic Risk Factors Biomarkers, Tumor Male Risk Assessment
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Predicting Survival in Patients with Advanced NSCLC Treated with Atezolizumab Using Pre- and on-Treatment Prognostic Biomarkers.

Clinical pharmacology and therapeutics Jul 12, 2024
Existing survival prediction models rely only on baseline or tumor kinetics data and lack machine learning integration. We introduce a novel kinetics-machine learning (kML) model that integrates baseline markers, tumor kinetics, and four on-treatment...
Humans Immune Checkpoint Inhibitors Aged Clinical Trials, Phase II as Topic Lung Neoplasms Biomarkers, Tumor Clinical Trials, Phase III as Topic Antibodies, Monoclonal, Humanized Carcinoma, Non-Small-Cell Lung Male Machine Learning Middle Aged Prognosis Female
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Machine Learning Predicts Oxaliplatin Benefit in Early Colon Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology Feb 5, 2024
PURPOSE: A combination of fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is the standard for adjuvant therapy of resected early-stage colon cancer (CC). Oxaliplatin leads to lasting and disabling neurotoxicity. Reserving the regimen for patients ...
Chemotherapy, Adjuvant Clinical Trials, Phase III as Topic Organoplatinum Compounds Leucovorin Oxaliplatin Neoplasm Staging Colonic Neoplasms Fluorouracil Humans Male Machine Learning Middle Aged Female Antineoplastic Combined Chemotherapy Protocols Aged Adult
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External Validation of a Digital Pathology-based Multimodal Artificial Intelligence Architecture in the NRG/RTOG 9902 Phase 3 Trial.

European urology oncology Feb 1, 2024
BACKGROUND: Accurate risk stratification is critical to guide management decisions in localized prostate cancer (PCa). Previously, we had developed and validated a multimodal artificial intelligence (MMAI) model generated from digital histopathology ...
Prostatic Neoplasms Clinical Trials, Phase III as Topic Male Middle Aged Risk Assessment Randomized Controlled Trials as Topic Humans Artificial Intelligence Prognosis Aged
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Application of statistical machine learning in biomarker selection.

Scientific reports Oct 26, 2023
In the recent JAVELIN Bladder 100 phase 3 trial, avelumab plus best supportive care significantly prolonged overall survival relative to best supportive care alone as first-line maintenance therapy following first-line platinum-based chemotherapy in ...
Humans Machine Learning Biomarkers Computer Simulation Prognosis Bayes Theorem Clinical Trials, Phase III as Topic
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Randomized controlled phase III trial to investigate superiority of robot-assisted gastrectomy over laparoscopic gastrectomy for clinical stage T1-4aN0-3 gastric cancer patients (JCOG1907, MONA LISA study): a study protocol.

BMC cancer Oct 17, 2023
BACKGROUND: Laparoscopic gastrectomy (LG) is considered a standard treatment for clinical stage I gastric cancer. Nevertheless, LG has some drawbacks, such as motion restriction and difficulties in spatial perception. Robot-assisted gastrectomy (RG) ...
Robotic Surgical Procedures Gastrectomy Clinical Trials, Phase III as Topic Humans Multicenter Studies as Topic Stomach Neoplasms Randomized Controlled Trials as Topic Postoperative Complications Robotics Treatment Outcome Laparoscopy
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Development of machine learning support for reading whole body diffusion-weighted MRI (WB-MRI) in myeloma for the detection and quantification of the extent of disease before and after treatment (MALIMAR): protocol for a cross-sectional diagnostic test accuracy study.

BMJ open Oct 5, 2022
INTRODUCTION: Whole-body MRI (WB-MRI) is recommended by the National Institute of Clinical Excellence as the first-line imaging tool for diagnosis of multiple myeloma. Reporting WB-MRI scans requires expertise to interpret and can be challenging for ...
Whole Body Imaging Diagnostic Tests, Routine Humans Multiple Myeloma Clinical Trials, Phase III as Topic Magnetic Resonance Imaging Machine Learning Chlorobenzenes Retrospective Studies Clinical Trials, Phase II as Topic Cross-Sectional Studies Sulfides
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Prediction of clinical trial enrollment rates.

PloS one Feb 24, 2022
Clinical trials represent a critical milestone of translational and clinical sciences. However, poor recruitment to clinical trials has been a long standing problem affecting institutions all over the world. One way to reduce the cost incurred by ins...
Forecasting Models, Theoretical Natural Language Processing Patient Selection Clinical Trials, Phase III as Topic Humans Clinical Trials, Phase I as Topic Censuses Machine Learning Translational Science, Biomedical Algorithms
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A Simulation Study to Compare the Predictive Performance of Survival Neural Networks with Cox Models for Clinical Trial Data.

Computational and mathematical methods in medicine Nov 28, 2021
BACKGROUND: Studies focusing on prediction models are widespread in medicine. There is a trend in applying machine learning (ML) by medical researchers and clinicians. Over the years, multiple ML algorithms have been adapted to censored data. However...
Male Clinical Trials, Phase III as Topic Randomized Controlled Trials as Topic Computational Biology Algorithms Data Interpretation, Statistical Humans Osteosarcoma Computer Simulation Clinical Trials as Topic Neural Networks, Computer Bone Neoplasms Prognosis Proportional Hazards Models Machine Learning Female
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