Predicting autoimmune thyroiditis in primary Sjogren's syndrome patients using a random forest classifier: a retrospective study.

Journal: Arthritis research & therapy
PMID:

Abstract

BACKGROUND: Primary Sjogren's syndrome (pSS) and autoimmune thyroiditis (AIT) share overlapping genetic and immunological profiles. This retrospective study evaluates the efficacy of machine learning algorithms, with a focus on the Random Forest Classifier, to predict the presence of thyroid-specific autoantibodies (TPOAb and TgAb) in pSS patients.

Authors

  • Jia-Yun Wu
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Jing-Yu Zhang
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Wen-Qi Xia
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Yue-Ning Kang
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Ru-Yi Liao
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Yu-Ling Chen
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Xiao-Min Li
    National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.
  • Ya Wen
    computer technology from Ningxia University, China.
  • Fan-Xuan Meng
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Li-Ling Xu
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Sheng-Hui Wen
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Hui-Fen Liu
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
  • Yuan-Qing Li
    School of Automation Science and Engineering, South China University of Technology, Guangzhou, China.
  • Jie-Ruo Gu
    Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China. gujieruo@163.com.
  • Qing Lv
    School of Water Resources and Environment, MOE Key Laboratory of Groundwater Circulation and Environmental Evolution, China University of Geosciences (Beijing), Beijing 100083, PR China.
  • Yong Ren
    Artificial Intelligence Innovation Center, Research Institute of Tsinghua, Pearl River Delta, Guangzhou, China.