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Sjogren's Syndrome

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Evaluation of minor labial salivary gland focus score in Sjögren's disease using deep learning: a tool for more efficient diagnosis and future tissue biomarker discovery.

Journal of autoimmunity
BACKGROUND: Sjögren's Disease (SjD) is histopathologically characterized by focal sialadenitis in minor labial salivary gland biopsies (mLSGB), which is evaluated by utilizing the focus score (FS). Focus score ≥1 identification is a critical step of ...

Raman hyperspectroscopy of saliva and machine learning for Sjögren's disease diagnostics.

Scientific reports
Sjögren's disease is an autoimmune disorder affecting exocrine glands, causing dry eyes and mouth and other morbidities. Polypharmacy or a history of radiation to the head and neck can also lead to dry mouth. Sjogren's disease is often underdiagnosed...

Research on disease diagnosis based on teacher-student network and Raman spectroscopy.

Lasers in medical science
Diabetic nephropathy is a serious complication of diabetes, and primary Sjögren's syndrome is a disease that poses a major threat to women's health. Therefore, studying these two diseases is of practical significance. In the field of spectral analysi...

The Florida Scoring System for stratifying children with suspected Sjögren's disease: a cross-sectional machine learning study.

The Lancet. Rheumatology
BACKGROUND: Childhood Sjögren's disease is a rare, underdiagnosed, and poorly-understood condition. By integrating machine learning models on a paediatric cohort in the USA, we aimed to develop a novel system (the Florida Scoring System) for stratify...

Automated segmentation and deep learning classification of ductopenic parotid salivary glands in sialo cone-beam CT images.

International journal of computer assisted radiology and surgery
PURPOSE: This study addressed the challenge of detecting and classifying the severity of ductopenia in parotid glands, a structural abnormality characterized by a reduced number of salivary ducts, previously shown to be associated with salivary gland...

Exploration of the shared diagnostic genes and mechanisms between periodontitis and primary Sjögren's syndrome by integrated comprehensive bioinformatics analysis and machine learning.

International immunopharmacology
BACKGROUND: Accumulating evidence has showed a bidirectional link between periodontitis (PD) and primary Sjögren's syndrome (pSS), but the mechanisms of their occurrence remain unclear. Hence, this study aimed to investigate the shared diagnostic gen...

Analysis of the relationships between interferon-stimulated genes and anti-SSA/Ro 60 antibodies in primary Sjögren's syndrome patients via multiomics and machine learning methods.

International immunopharmacology
BACKGROUND: Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocyte infiltration of the exocrine glands. Interferon-stimulated genes (ISGs) are often upregulated in patients with pSS, and anti-SSA/Ro 60 a...

Predicting autoimmune thyroiditis in primary Sjogren's syndrome patients using a random forest classifier: a retrospective study.

Arthritis research & therapy
BACKGROUND: Primary Sjogren's syndrome (pSS) and autoimmune thyroiditis (AIT) share overlapping genetic and immunological profiles. This retrospective study evaluates the efficacy of machine learning algorithms, with a focus on the Random Forest Clas...

Deep learning in the precise assessment of primary Sjögren's syndrome based on ultrasound images.

Rheumatology (Oxford, England)
OBJECTIVES: This study aimed to investigate the value of a deep learning (DL) model based on greyscale ultrasound (US) images for precise assessment and accurate diagnosis of primary Sjögren's syndrome (pSS).