Clinical Validation of a Deep Learning Algorithm for Automated Coronary Artery Disease Detection and Classification Using a Heterogeneous Multivendor Coronary Computed Tomography Angiography Data Set.

Journal: Journal of thoracic imaging
Published Date:

Abstract

PURPOSE: We sought to clinically validate a fully automated deep learning (DL) algorithm for coronary artery disease (CAD) detection and classification in a heterogeneous multivendor cardiac computed tomography angiography data set.

Authors

  • Emanuele Muscogiuri
    Department of Radiology and Imaging Sciences, Emory University Hospital | Emory Healthcare, Inc., Atlanta, GA, USA; Thoracic Imaging Division, Department of Radiology, University Hospitals Leuven, Leuven, Belgium.
  • Marly van Assen
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260 (S.S.M., D.M., M.v.A., C.N.D.C., R.R.B., C.T., A.V.S., A.M.F., B.E.J., L.P.G., U.J.S.); Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (S.S.M., T.J.V.); Stanford University School of Medicine, Department of Radiology, Stanford, Calif (D.M.); Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (C.N.D.C.); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.R.B.); Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany (C.T.); Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Munich, Germany (C.T.); Siemens Medical Solutions USA, Malvern, Pa (P.S.); and Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC (A.J.M.).
  • Giovanni Tessarin
    Department of Radiology and Imaging Sciences, Emory University Hospital | Emory Healthcare, Inc., Atlanta, GA, USA; Department of Medicine-DIMED, Institute of Radiology, University of Padova, Padua, Italy; Department of Radiology, Ca' Foncello General Hospital, Treviso, Italy.
  • Alexander C Razavi
    Translational Laboratory for Cardiothoracic Imaging and Artificial Intelligence, Emory University, 2015 Uppergate Dr, Atlanta, GA 30307, USA.
  • Max Schoebinger
    From the Division of Cardiovascular Imaging, Department of Radiology and Radiological Science (C.T., C.N.D.C., S.B., M.R., T.W.M., T.M.D., R.R.B., U.J.S.), and Division of Cardiology, Department of Medicine (R.R.B., D.H.S., U.J.S.), Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260; Department of Computed Tomography-Research & Development, Siemens Healthcare GmbH, Forchheim, Germany (K.L.G., C.C., C.S., M.S.); Department of Corporate Technology, Siemens SRL, Brasov, Romania (L.M.I.); and Department of Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ (S.R., P.S.).
  • Michael Wels
    Siemens Healthineers, Erlangen, Germany.
  • Mehmet Akif Gulsun
    Siemens Healthineers, Princeton, NJ, USA.
  • Puneet Sharma
    Digital Technologies and Innovation, Siemens Healthineers, Princeton, NJ, United States.
  • George S K Fung
    Siemens Healthineers, Malvern, PA, USA.
  • Carlo N De Cecco
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260 (S.S.M., D.M., M.v.A., C.N.D.C., R.R.B., C.T., A.V.S., A.M.F., B.E.J., L.P.G., U.J.S.); Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (S.S.M., T.J.V.); Stanford University School of Medicine, Department of Radiology, Stanford, Calif (D.M.); Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (C.N.D.C.); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.R.B.); Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany (C.T.); Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Munich, Germany (C.T.); Siemens Medical Solutions USA, Malvern, Pa (P.S.); and Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC (A.J.M.).