Development and validation of explainable machine learning models for female hip osteoporosis using electronic health records.

Journal: International journal of medical informatics
PMID: 40132236

Abstract

BACKGROUND: Hip fractures are associated with reduced mobility, and higher morbidity, mortality, and healthcare costs. Approximately 90% of hip fractures in the elderly are associated with osteoporosis, making it particularly important to screen the population for hip osteoporosis and intervene early. Dual-energy X-ray absorptiometry (DXA) has limited accessibility, so predictive models for hip osteoporosis that do not use bone mineral density (BMD) data are essential. We aimed to develop and validate prediction models for female hip osteoporosis using electronic health records without BMD data.

Authors

  • Wanlin Jin
    Health Management Center, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Department of General Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address: wanlin.jin@csu.edu.cn.
  • Lulu Xu
    College of Software, Jiangxi Agricultural University, Nanchang 330045, People's Republic of China.
  • Chun Yue
    Health Management Center, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address: yuechun@csu.edu.cn.
  • Li Hu
    CAS Key Laboratory of Mental Health, Institute of Psychology (CAS) Beijing, China.
  • Yuzhou Wang
    Health Management Center, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address: 386634407@qq.com.
  • Yaqian Fu
    Health Management Center, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address: fuyaqian@csu.edu.cn.
  • Yuanwei Guo
    Health Management Center, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address: guoyuanwei0501@csu.edu.cn.
  • Fan Bai
    School of Information Engineering, Chang'an University, Xi'an 710010, China.
  • Yanyi Yang
    Health Management Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Xianmei Zhao
    Health Management Center, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address: 1181812707@qq.com.
  • Yingquan Luo
    Department of General Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address: luoyingquan@csu.edu.cn.
  • Xiyu Wu
    Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
  • Zhifeng Sheng
    Health Management Center, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Clinical Medicine Research Center for Intelligent Management of Chronic Disease, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya, Hospital of Central South University, Changsha, Hunan, China. Electronic address: shengzhifeng@csu.edu.cn.

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