Development and validation of pan-cancer lesion segmentation AI-model for whole-body 18F-FDG PET/CT in diverse clinical cohorts.

Journal: Computers in biology and medicine
PMID:

Abstract

BACKGROUND: This study develops a deep learning-based automated lesion segmentation model for whole-body 3DF-fluorodeoxyglucose (FDG)-Position emission tomography (PET) with computed tomography (CT) images agnostic to disease location and site.

Authors

  • Fahmida Haque
    Artificial Intelligence Resource, Molecular Imaging Branch, National Cancer Institute, Bethesda, MD, USA.
  • Alex Chen
    Artificial Intelligence Resource, National Cancer Institute, National Institute of Health, Bethesda, MD, 20814, USA.
  • Nathan Lay
    Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Clinical Image Processing Service, Radiology and Imaging Sciences Department, National Institutes of Health Clinical Center, Bethesda, MD 20892-1182, USA.
  • Jorge Carrasquillo
    Molecular Imaging Branch, National Cancer Institute, National Institute of Health, Bethesda, MD, 20892, USA.
  • Esther Mena
    Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr., MSC 1182, Building 10, Room B3B85, Bethesda, Maryland, USA (M.J.B., S.A.H., N.S.L., E.C.Y., T.E.P., B.S., L.L., E.M., P.L.C., B.T.).
  • Liza Lindenberg
    Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr., MSC 1182, Building 10, Room B3B85, Bethesda, Maryland, USA (M.J.B., S.A.H., N.S.L., E.C.Y., T.E.P., B.S., L.L., E.M., P.L.C., B.T.).
  • Julia E Segal
    Section on Medical Neuroendocrinology National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Philip C Eclarinal
    Molecular Imaging Branch, National Cancer Institute, National Institute of Health, Bethesda, MD, 20892, USA.
  • Sara Talvacchio
    Section on Medical Neuroendocrinology National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Alberta Derkyi
    Section on Medical Neuroendocrinology National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892, MD, USA.
  • Peter L Choyke
    Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Karel Pacak
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
  • Rosandra N Kaplan
    Pediatric Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD, 20892, USA.
  • Frank I Lin
    Molecular Imaging Branch, National Cancer Institute, National Institute of Health, Bethesda, MD, 20892, USA.
  • Baris Turkbey
    Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Stephanie A Harmon
    Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, USA.