Identification of hypertension subtypes using microRNA profiles and machine learning.

Journal: European journal of endocrinology
PMID: 40105001

Abstract

OBJECTIVE: Hypertension is a major cardiovascular risk factor affecting about 1 in 3 adults. Although the majority of hypertension cases (∼90%) are classified as "primary hypertension" (PHT), endocrine hypertension (EHT) accounts for ∼10% of cases and is caused by underlying conditions such as primary aldosteronism (PA), Cushing's syndrome (CS), pheochromocytoma or paraganglioma (PPGL). EHT is often misdiagnosed as PHT leading to delays in treatment for the underlying condition, reduced quality of life and costly, often ineffective, antihypertensive treatment. MicroRNA (miRNA) circulating in the plasma is emerging as an attractive potential biomarker for various clinical conditions due to its ease of sampling, the accuracy of its measurement and the correlation of particular disease states with circulating levels of specific miRNAs.

Authors

  • Smarti Reel
    Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, United Kingdom.
  • Parminder S Reel
    Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, United Kingdom.
  • Josie Van Kralingen
    School of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom.
  • Casper K Larsen
    Université Paris Cité, Inserm, PARCC, Paris, France.
  • Stacy Robertson
    School of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom.
  • Scott M MacKenzie
    School of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom.
  • Alexandra Riddell
    School of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom.
  • John D McClure
    School of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom.
  • Stelios Lamprou
    School of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom.
  • John M C Connell
    Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD2 4BF, United Kingdom.
  • Laurence Amar
    Clinical Investigation Center (CIC) 1418 Clinical Epidemiology, Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
  • Alessio Pecori
    Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy.
  • Martina Tetti
    From the Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Italy (F.B., J.B., R.C., V.F., E.S., M.T., F.V., T.A.W., P.M., S.M.).
  • Christina Pamporaki
    Department of Medicine III, University Hospital Carl Gustav Carus, TU Dresden, Germany.
  • Marek Kabat
    Department of Hypertension, National Institute of Cardiology, Warsaw, Poland.
  • Filippo Ceccato
    Endocrinology Unit, Department of Medicine, University of Padova, Italy (F.C.).
  • Matthias Kroiss
    Department of Internal Medicine, Division of Endocrinology, University Hospital, University of Würzburg, Würzburg, Germany.
  • Michael C Dennedy
    The Discipline of Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland.
  • Anthony Stell
    School of Computing and Information Systems, The University of Melbourne, Melbourne, Australia.
  • Jaap Deinum
    Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Paolo Mulatero
    Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy.
  • Martin Reincke
    Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany.
  • Anne-Paule Gimenez-Roqueplo
    Université Paris Cité, Inserm, PARCC, Paris, France.
  • Guillaume Assié
    Université Paris Cité, Faculté de Médecine, Paris 75006, France; Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris 75014, France.
  • Anne Blanchard
    Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Centre d'Investigations Cliniques, Paris 9201, France.
  • Felix Beuschlein
    Medizinische Klinik and Poliklinik IV, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Gian Paolo Rossi
    Internal and Emergency Medicine-ESH Specialized Hypertension Center, Department of Medicine-DIMED, University of Padua, Padua, Italy.
  • Graeme Eisenhofer
    Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Maria-Christina Zennaro
    Université Paris Cité, Inserm, PARCC, Paris, France.
  • Emily Jefferson
    Division of Population Health and Genomics, Ninewells Hospital and Medical School, Dundee DD1 9SY.
  • Eleanor Davies
    School of Cardiovascular and Metabolic Health, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, United Kingdom.

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