Deep Learning-Based Chronic Obstructive Pulmonary Disease Exacerbation Prediction Using Flow-Volume and Volume-Time Curve Imaging: Retrospective Cohort Study.

Journal: Journal of medical Internet research
PMID:

Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common and progressive respiratory condition characterized by persistent airflow limitation and symptoms such as dyspnea, cough, and sputum production. Acute exacerbations (AE) of COPD (AE-COPD) are key determinants of disease progression; yet, existing predictive models relying mainly on spirometric measurements, such as forced expiratory volume in 1 second, reflect only a fraction of the physiological information embedded in respiratory function tests. Recent advances in artificial intelligence (AI) have enabled more sophisticated analyses of full spirometric curves, including flow-volume loops and volume-time curves, facilitating the identification of complex patterns associated with increased exacerbation risk.

Authors

  • Eun-Tae Jeon
    Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea; Medical Science Research Center, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea. Electronic address: gksmfskdls@gmail.com.
  • Heemoon Park
    Department of Internal Medicine, Division of Respiratory and Critical Care, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
  • Jung-Kyu Lee
    From the Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Chongno-gu, Seoul 03080, Korea (S.L., J.M.G., S.H.Y.); Division of Pulmonary and Critical Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea (J.J.Y., N.K.); Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea (Y.J.L.); Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea (J.K.L.); Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea (J.Y.L.); Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea (J.S.K.); Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (Y.A.K.); Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea (D.J.); Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Korea (M.J.J.); Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea (J.M.G.); and Department of Radiology, UMass Memorial Medical Center, Worcester, Mass (S.H.Y.).
  • Eun Young Heo
    Division of Respiratory and Critical Care, Department of Internal Medicine.
  • Chang Hoon Lee
    From the Department of Radiology (H.K., S.H.Y.), Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine (C.H.L., S.M.L.), and Medical Research Collaborating Center (H.H.), Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea; Department of Radiology, Seoul National University College of Medicine, Seoul, Korea (H.K., K.N.J., S.H.Y.); Department of Radiology, SMG-SNU Boramae Medical Center, Seoul, Korea (K.N.J.); Department of Radiology, Hanyang University Medical Center, Seoul, Korea (S.J.Y.); and MEDICAL IP, Seoul, Korea (J.N.W., S.H.Y.).
  • Deog Kyeom Kim
    Division of Respiratory and Critical Care, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
  • Dong Hyun Kim
    Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.
  • Hyun Woo Lee
    Division of Respiratory and Critical Care, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.