Evaluation of a Deep Learning Denoising Algorithm for Dose Reduction in Whole-Body Photon-Counting CT Imaging: A Cadaveric Study.

Journal: Academic radiology
Published Date: Jun 1, 2025

Abstract

RATIONALE AND OBJECTIVES: Photon Counting CT (PCCT) offers advanced imaging capabilities with potential for substantial radiation dose reduction; however, achieving this without compromising image quality remains a challenge due to increased noise at lower doses. This study aims to evaluate the effectiveness of a deep learning (DL)-based denoising algorithm in maintaining diagnostic image quality in whole-body PCCT imaging at reduced radiation levels, using real intraindividual cadaveric scans.

Authors

  • Reza Dehdab
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls University, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany (A.S.B., R.D., B.S., J.M., P.G., G.G., S.A., C.A.).
  • Jan M Brendel
    Department of Radiology, Diagnostic and Interventional Radiology, University of Tübingen, 72076 Germany.
  • Sebastian Streich
    Institute of Clinical Anatomy and Cell Analysis, Eberhard Karls University of Tuebingen, Elfriede-Aulhorn-Str 8, 72076, Tuebingen, Germany (S.S., R.L.).
  • Ruth Ladurner
    Institute of Clinical Anatomy and Cell Analysis, Eberhard Karls University of Tuebingen, Elfriede-Aulhorn-Str 8, 72076, Tuebingen, Germany (S.S., R.L.).
  • Benedikt Stenzl
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls University, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany (A.S.B., R.D., B.S., J.M., P.G., G.G., S.A., C.A.).
  • Jonas Mueck
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls University, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany (A.S.B., R.D., B.S., J.M., P.G., G.G., S.A., C.A.).
  • Sebastian Gassenmaier
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA.
  • Patrick Krumm
    Department of Radiology, Diagnostic and Interventional Radiology, University of Tübingen, 72076 Germany. Electronic address: patrick.krumm@med.uni-tuebingen.de.
  • Sebastian Werner
  • Judith Herrmann
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen, Tuebingen, Germany.
  • Konstantin Nikolaou
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str.3, 72076 Tübingen, Germany.
  • Saif Afat
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen, Tuebingen, Germany.
  • Andreas Brendlin
    Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.

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