Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights.
Journal:
Microbial cell factories
PMID:
40340934
Abstract
BACKGROUND: The rising danger of antibiotic resistance and the increasing burden of cancer worldwide have highlighted the necessity for a constant supply of new antimicrobial drugs and anticancer therapies. Endophytic fungi, recognized as a rich supplier of secondary metabolites with novel bioactivities that have shown promising antimicrobial and anticancer potential, were isolated from the medicinal plant Calotropis procera. Approximately 70 segments from the leaves and stems of the C. procera plant were evaluated for endophytic colonization, resulting in the isolation and identification of five fungal species based on morphological characteristics.