AIMC Topic: Cell Line, Tumor
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Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation.
Nature communications
Aug 9, 2025
Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast forma...
Detection of Unlabeled Polystyrene Micro- and Nanoplastics in Mammalian Tissue by Optical Photothermal Infrared Spectroscopy.
Analytical chemistry
Aug 1, 2025
In this study, we investigate the efficacy of optical photothermal infrared (O-PTIR) spectroscopy, also known as mid-infrared photothermal (MIP) microscopy, for label-free and nondestructive detection of micro- and nanoplastics (MNPs) down to diamete...
Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer.
Scientific reports
Jul 31, 2025
Colorectal cancer (CRC) treatment remains challenging due to genetic heterogeneity and resistance mechanisms. To address this, we developed a drug discovery pipeline using patient-derived primary CRC cultures with diverse genomic profiles. These cult...
Machine learning-assisted exploration of multidrug-drug administration regimens for organoid arrays.
Science advances
Jul 30, 2025
Combination therapies enhance the therapeutic effect of cancer treatment; however, identifying effective interdependent doses, durations, and sequences of multidrug administration regimens is a time- and labor-intensive task. Here, we integrated mach...
Data-Driven Sustainable Campaigns to Decipher Invasive Breast Cancer Features.
ACS biomaterials science & engineering
Jul 25, 2025
The intrinsic complexity of biological processes often hides the role of dynamic microenvironmental cues in the development of pathological states. Microphysiological systems (MPSs) are emerging technological platforms that model dynamics of tissue-...
Machine Learning-Enhanced Single-Particle Tracking for Rapid Screening of Tumor Immunomodulatory Drugs.
ACS nano
Jul 21, 2025
The tumor microenvironment plays a critical role in tumor progression and immune response, with the extracellular matrix (ECM) regulating immune cell infiltration. However, the interplay between ECM dynamics and tumor immunity remains poorly understo...
Ferroptosis-disulfidptosis-related CHMP6 is a clinico-immune target in colorectal cancer.
Biology direct
Jul 21, 2025
BACKGROUND: Ferroptosis and disulfidptosis are newly discovered forms of regulated cell death that play critical roles in cancer progression, metabolism, and immune evasion. However, their interplay and combined influence on colorectal cancer (CRC) p...
Noninvasive real-time monitoring of cellular spatiotemporal dynamics via machine learning-enhanced electrical impedance spectroscopy.
Science advances
Jul 16, 2025
Monitoring cellular spatiotemporal dynamics is essential for understanding complex biological processes such as organ development and cancer progression. Using live-cell fluorescence microscopy to track cellular dynamics is often limited by dye-induc...
Multi-tissue Methylation Analysis of Alzheimer's Disease: Insights into Pathways, Modules, and Key Genes.
Journal of molecular neuroscience : MN
Jul 16, 2025
DNA methylation plays a crucial role in the onset and progression of Alzheimer's disease (AD). Genome-wide methylation analysis of multi-tissue data can provide insights into the pathology and diagnostic biomarkers of AD. Computational tools were emp...
Exploration of Predictive Potential of AI-enabled Portable System in Anticancer Drug Delivery: A Comparative Study with Modified Gompertz like Biphasic Response Model.
AAPS PharmSciTech
Jul 16, 2025
Mathematical models are conventionally used to understand the of tumor behaviors, but they generally lack in precisely correlating drug efficacy with tumor response. Artificial intelligence (AI) has forged a new avenue in cancer management, but requi...
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