Innovations in the diagnosis, treatment, and management of disorders of gut-brain interaction (DGBI).

Journal: Expert review of gastroenterology & hepatology
Published Date: Jun 1, 2025

Abstract

INTRODUCTION: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are the most prevalent disorders of gut-brain interaction (DGBI), frequently overlapping and associated with complex pathophysiological mechanisms. Increasing evidence implicates gut microbiota alterations in driving symptoms via immune activation, altered motility, gut vascular barrier and gut-brain axis disruption.

Authors

  • Patrycja Krynicka
    Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland.
  • George Koulaouzidis
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
  • Wojciech Marlicz
    Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland; The Centre for Digestive Diseases, Endoklinika Sp. Z O.O. (Ltd) Spółka Komandytowa, Szczecin, Poland.
  • Anastasios Koulaouzidis
    Endoscopy Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.

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