National Guidelines for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Peritoneal Malignancies: A Worldwide Systematic Review and Recommendations of Strength Analysis.

Journal: Annals of surgical oncology
Published Date: Aug 1, 2025

Abstract

BACKGROUND: National guidelines (GLs) for surgical cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of peritoneal malignancies (PMs) vary across countries, scientific societies, and government agencies. This study aimed to systematically review and compare the recommendations for CRS/HIPEC in the treatment of ovarian cancer (EOC), gastric cancer, colorectal cancer (CRC), mesothelioma, and pseudomyxoma peritonei (PMP).

Authors

  • Marco Tonello
    Unit of Surgical Oncology of the Digestive Tract, Surgical Oncology Department, Veneto Institute of Oncology IOV-IRCCS, Padua, Castelfranco Veneto, TV, Italy. marco.tonello@iov.veneto.it.
  • Carola Cenzi
    Clinical Research Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
  • Elisa Pizzolato
    Unit of Surgical Oncology of the Digestive Tract, Surgical Oncology Department, Veneto Institute of Oncology IOV-IRCCS, Padua, Castelfranco Veneto, TV, Italy.
  • Manuela Martini
    Unit of Surgical Oncology of the Digestive Tract, Surgical Oncology Department, Veneto Institute of Oncology IOV-IRCCS, Padua, Castelfranco Veneto, TV, Italy.
  • Pierluigi Pilati
    Unit of Surgical Oncology of the Digestive Tract, Surgical Oncology Department, Veneto Institute of Oncology IOV-IRCCS, Padua, Castelfranco Veneto, TV, Italy.
  • Antonio Sommariva
    Unit of Surgical Oncology of the Digestive Tract, Surgical Oncology Department, Veneto Institute of Oncology IOV-IRCCS, Padua, Castelfranco Veneto, TV, Italy.

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