Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability.

Journal: Journal of nanobiotechnology
Published Date: May 26, 2025

Abstract

The blood-brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). Research in brain-targeted delivery strategies and explore in natural products for BBB modulation have opened new avenues for effective CNS drug delivery. This review highlights the latest developments in molecular-based delivery systems, cell-based approaches, physical techniques, toxicity concerns, clinical trials and artificial intelligence (AI) -driven modeling for brain-targeted drug delivery. Additionally, it examines the role of natural products, particularly aromatic resuscitation medicines, in enhancing BBB permeability through modulating tight junction proteins and inhibiting efflux transporters. It is emphasized that the integration of natural products with modern drug delivery systems offers promising opportunities for the development of novel brain-targeted therapies. However, challenges related to the complexity and variety of natural product compositions must be addressed to fully realize their potential. This review underscores the importance of continued research into the molecular mechanisms underlying BBB modulation and natural product-mediated nano-delivery strategies for CNS disorders.

Authors

  • Suyi Liu
    College of Humanities and Social Sciences, Guangxi Medical University, Nanning, China.
  • Xingyue Jin
    State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
  • Yuanyuan Ge
    Department of Cardiology, 920th Hospital of Joint Logistics Support Force, People's Liberation Army of China (PLA), Kunming, Yunnan, China.
  • Junlin Dong
    University of Chinese Academy of Sciences, Beijing 100049, China.
  • Xinyue Liu
    BDX Research and Consulting LLC, Herndon, VA, 20171, USA.
  • Xiao Pei
    NMPA Key Laboratory for Bioequivalence Research of Generic Drug Evaluation, Shenzhen Institute for Drug Control, Shenzhen, 518057, China.
  • Ping Wang
    School of Chemistry and Chemical Engineering, Shandong University of Technology, 255049, Zibo, PR China. Electronic address: wangping876@163.com.
  • Bing Wang
    Computer Science & Engineering Department at the University of Connecticut.
  • Yanxu Chang
    State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: Tcmcyx@tjutcm.cn.
  • Xie-An Yu
    Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

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