AIMC Topic: Blood-Brain Barrier
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Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier.
Journal of nanobiotechnology
Jul 8, 2025
The blood-brain barrier (BBB) poses a major challenge to the effective delivery of therapeutic agents for the treatment of central nervous system (CNS) disorders. The integration of cell membrane engineering with nanotechnology has recently enabled t...
3BTRON: A Blood-Brain Barrier Recognition Network.
Communications biology
Jul 4, 2025
The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis. During ageing, the BBB undergoes structural alterations. Electron microscopy (EM) is the gold standard for studying the structural alterations of the brain vasculatu...
AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy.
Pharmacological research
Jun 19, 2025
Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer's disease (AD). Nevertheless, the development of brain-penetrant small-molecule Gal-3 inhibitors poses a significant challeng...
Role of tight junctions in three-dimensional mechanical model of blood-brain barrier.
Journal of biomechanics
Jun 7, 2025
The increasing prevalence of central nervous system (CNS) disorders has imposed a significant social and economic burden on healthcare systems. The blood-brain barrier (BBB) presents a major challenge for effective drug delivery to the brain, hinderi...
Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability.
Journal of nanobiotechnology
May 26, 2025
The blood-brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). Research in brain-targeted delivery strategies a...
GCN-BBB: Deep Learning Blood-Brain Barrier (BBB) Permeability PharmacoAnalytics with Graph Convolutional Neural (GCN) Network.
The AAPS journal
Apr 3, 2025
The Blood-Brain Barrier (BBB) is a selective barrier between the Central Nervous System (CNS) and the peripheral system, regulating the distribution of molecules. BBB permeability has been crucial in CNS-targeting drug development, such as glioblasto...
Multiple Instance Learning-Based Prediction of Blood-Brain Barrier Opening Outcomes Induced by Focused Ultrasound.
IEEE transactions on bio-medical engineering
Mar 21, 2025
OBJECTIVE: Targeted blood-brain barrier (BBB) opening using focused ultrasound (FUS) and micro/nanobubbles is a promising method for brain drug delivery. This study aims to explore the feasibility of multiple instance learning (MIL) in accurate and f...
Molecular Generation for CNS Drug Discovery and Design.
ACS chemical neuroscience
Mar 13, 2025
Computational drug design is a rapidly evolving field, especially the latest breakthroughs in generative artificial intelligence (GenAI) to create new compounds. However, the potential of GenAI to address the challenges in designing central nervous s...
Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.
ACS nano
Mar 5, 2025
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the cl...
Enhancing Blood-Brain Barrier Penetration Prediction by Machine Learning-Based Integration of Novel and Existing, In Silico and Experimental Molecular Parameters from a Standardized Database.
Journal of chemical information and modeling
Mar 4, 2025
Predicting blood-brain barrier (BBB) penetration is crucial for developing central nervous system (CNS) drugs, representing a significant hurdle in successful clinical phase I studies. One of the most valuable properties for this prediction is the po...
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