NeuroXiv: AI-powered open databasing and dynamic mining of brain-wide neuron morphometry.

Journal: Nature methods
Published Date: Apr 29, 2025

Abstract

Neuron morphology has been extensively reconstructed at the whole-brain scale by various projects in recent years. Here, to facilitate interactive exploration in a standardized and scalable manner, we introduce NeuroXiv (neuroxiv.org), a large-scale database containing 175,149 reconstructed neuron morphologies mapped to the Common Coordinate Framework Version 3 (CCFv3). In addition, NeuroXiv incorporates an AI-powered mining engine (AIPOM) for dynamic, user-specific data mining, delivering enhanced performance via a custom client program.

Authors

  • Shengdian Jiang
    New Cornerstone Science Laboratory, SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
  • Lijun Wang
    Department of Stomatology, The Third Medical Center Chinese PLA General Hospital Beijing China.
  • Zhixi Yun
    New Cornerstone Science Laboratory, SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.
  • Hanbo Chen
    Allen Institute for Brain Science, Seattle, WA, USA. cojoc.chen@gmail.com.
  • Lijuan Liu
    New Cornerstone Science Laboratory, SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, Jiangsu 210096, China.
  • Jianhua Yao
  • Hanchuan Peng
    New Cornerstone Science Laboratory, SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, Jiangsu 210096, China.

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