Fecal gut microbiota and amino acids as noninvasive diagnostic biomarkers of Pediatric inflammatory bowel disease.

Journal: Gut microbes
Published Date:

Abstract

BACKGROUND AND AIMS: Fecal calprotectin (FCP) has limited specificity as diagnostic biomarker of pediatric inflammatory bowel disease (IBD), leading to unnecessary invasive endoscopies. This study aimed to develop and validate a fecal microbiota and amino acid (AA)-based diagnostic model.

Authors

  • Eva Vermeer
    Department of Paediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Amsterdam, The Netherlands.
  • Jasmijn Z Jagt
    Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Eline M Lap
    Faculty of Medicine, University of Amsterdam, Amsterdam, the Netherlands.
  • Eduard A Struys
    Department of Laboratory Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
  • Andries E Budding
    Inbiome BV, Amsterdam, The Netherlands.
  • Nanda M Verhoeven-Duif
    Section Metabolic Diagnostics, Department of Genetics, University Medical Centre Utrecht, Utrecht University, Lundlaan 6, 3584 EA Utrecht, The Netherlands.
  • Marjolein Bosma
    Department of Genetics, Section Metabolic Diagnostics, UMC Utrecht, Utrecht, The Netherlands.
  • Johan E Van Limbergen
    Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Academic Medical Centre, Amsterdam, The Netherlands.
  • Bart G P Koot
    Department of Paediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Amsterdam, The Netherlands.
  • Robert de Jonge
    Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit & University of Amsterdam, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands. Electronic address: r.dejonge1@amsterdamumc.nl.
  • Marc A Benninga
    Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Academic Medical Centre, Amsterdam, The Netherlands.
  • Animesh Acharjee
    College of Medicine and Health, School of Medical Sciences, Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
  • Nanne K H de Boer
    Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute, Amsterdam University Medical Centre, VU University Amsterdam, Amsterdam, The Netherlands.
  • Tim G J de Meij
    Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.