A skin-interfaced wireless wearable device and data analytics approach for sleep-stage and disorder detection.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published Date:

Abstract

Accurate identification of sleep stages and disorders is crucial for maintaining health, preventing chronic conditions, and improving diagnosis and treatment. Direct respiratory measurements, as key biomarkers, are missing in traditional wrist- or finger-worn wearables, which thus limit their precision in detection of sleep stages and sleep disorders. By contrast, this work introduces a simple, multimodal, skin-integrated, energy-efficient mechanoacoustic sensor capable of synchronized cardiac and respiratory measurements. The mechanical design enhances sensitivity and durability, enabling continuous, wireless monitoring of essential vital signs (respiration rate, heart rate and corresponding variability, temperature) and various physical activities. Systematic physiology-based analytics involving explainable machine learning allows both precise sleep characterization and transparent tracking of each factor's contribution, demonstrating the dominance of respiration, as validated through a diverse range of human subjects, both healthy and with sleep disorders. This methodology enables cost-effective, clinical-quality sleep tracking with minimal user effort, suitable for home and clinical use.

Authors

  • Yayun Du
    Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208.
  • Jianyu Gu
    Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208.
  • Shiyuan Duan
    Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208.
  • Jacob Trueb
    Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208.
  • Andreas Tzavelis
    Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208.
  • Hee-Sup Shin
    Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208.
  • Hany Arafa
    Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208.
  • Xiuyuan Li
    Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208.
  • Yonggang Huang
    Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Andrew N Carr
    Procter & Gamble Company, Cincinnati, OH 45224.
  • Charles R Davies
    Carle Neuroscience Institute, Carle Health, Urbana, IL 61801.
  • John A Rogers
    7Center for Bio-Integrated Electronics, Departments of Materials Science and Engineering, Biomedical Engineering, Chemistry, Mechanical Engineering, Electrical Engineering and Computer Science, Neurological Surgery, Simpson Querrey Institute for Nano/Biotechnology, McCormick School of Engineering, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208 USA.