Elevated tissue factor pathway inhibitor is associated with intracerebral haemorrhage of unknown cause in young adults.
Journal:
Neurologia i neurochirurgia polska
PMID:
39737585
Abstract
CLINICAL RATIONALE FOR STUDY: We have reported that intracerebral haemorrhage (ICH) of unknown cause at a young age is associated with lower prothrombin and factor VII and higher antithrombin activity, along with the formation of looser fibrin networks displaying enhanced lysability. Patients with mild-to-moderate bleeding of unknown cause have elevated levels of free plasma tissue factor pathway inhibitor alpha (fTFPIα), inhibiting the tissue factor-factor VII complex and prothrombinase.