Computational modelling for risk assessment of neurological disorder in diabetes using Hodgkin-Huxley model.
Journal:
Computer methods and programs in biomedicine
Published Date:
Apr 20, 2025
Abstract
BACKGROUND: Diabetes mellitus, characterized by chronic glucose dysregulation, significantly increases the risk of neurological disorders such as cognitive decline, seizures, and Alzheimer's disease. As neurons depend on glucose for energy, fluctuations in glucose levels can disrupt sodium (Na⁺) and potassium (K⁺) ion channel dynamics, leading to altered membrane potential. Modeling these ionic changes enables the simulation of neuronal responses under glycemic extremes, providing valuable insights for risk assessment and personalized treatment.
