ognitive utcomes in the ragmatic nvestigation of optimaxygen argets (CO-PILOT) trial: protocol and statistical analysis plan.

Journal: BMJ open
Published Date: Nov 1, 2022

Abstract

INTRODUCTION: Long-term cognitive impairment is one of the most common complications of critical illness among survivors who receive mechanical ventilation. Recommended oxygen targets during mechanical ventilation vary among international guidelines. Different oxygen targets during mechanical ventilation have the potential to alter long-term cognitive function due to cerebral hypoxemia or hyperoxemia. Whether higher, intermediate or lower SpO targets are associated with better cognitive function at 12-month follow-up is unknown.

Authors

  • Matthew F Mart
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA matthew.f.mart@vumc.org.
  • Matthew W Semler
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Gordon Bernard
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Jonathan D Casey
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • E Wesley Ely
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Robert Freundlich
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • James C Jackson
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Amy Kiehl
    Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Cathy Jenkins
    Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Guanchao Wang
    Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Christopher Lindsell
    Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Patsy Bryant
    Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Todd W Rice
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Wesley H Self
    Vanderbilt Institute for Clinical and Translational Research (VICTR), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Joanna Stollings
    Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Jonathan P Wanderer
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Li Wang
    College of Marine Electrical Engineering, Dalian Maritime University, Dalian, China.
  • Jin Ho Han
    Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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