External Validation of a Machine Learning Model to Diagnose Kawasaki Disease.

Journal: The Journal of pediatrics
Published Date:

Abstract

We investigated the generalizability of a machine learning model trained to predict Kawasaki disease using laboratory and clinical data. The algorithm performed with >89% accuracy at 3 children's hospitals across the United States, demonstrating its potential as a physician support tool for diagnosing Kawasaki disease.

Authors

  • Jonathan Y Lam
  • Chisato Shimizu
    Department of Pediatrics, Kawasaki Disease Research Center, University of California San Diego, La Jolla, CA 92093.
  • Michael A Gardiner
  • Thomas Giorgio
    Department of Cardiology, Boston Children's Hospital, Boston, MA.
  • Veronique Wright
    Department of Cardiology, Boston Children's Hospital, Boston, MA.
  • Annette Baker
    Department of Cardiology, Boston Children's Hospital, Boston, MA.
  • Marsha S Anderson
    Department of Pediatrics, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO.
  • Heather Heizer
    Department of Pediatric Infectious Diseases, Oklahoma Children's Hospital and University of Oklahoma Health Science Center, Oklahoma City, OK.
  • Sindhu Mohandas
    Division of Infectious Disease, Children's Hospital Los Angeles and Keck School of Medicine of the University of Southern California, Los Angeles, CA.
  • Alicia Kazarians
    Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA.
  • Kelli Kaneta
    Division of Nephrology, Children's Hospital Los Angeles, Los Angeles, CA.
  • Pei-Ni Jone
    Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL.
  • Samuel R Dominguez
    Department of Pediatrics, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO.
  • Jacqueline R Szmuszkovicz
    Division of Cardiology, Children's Hospital Los Angeles and Keck School of Medicine of the University of Southern California, Los Angeles, CA.
  • Jane W Newburger
    Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.
  • Adriana H Tremoulet
    Department of Clinical Pharmacy (GJK, GR, AHT), Rady Children's Hospital San Diego, California, Department of Pediatrics (EC, AHT), University of California, San Diego, Clinical and Translational Research Institute (JAP), University of California, San Diego.
  • Jane C Burns
    Department of Pediatrics, University of California at San Diego, La Jolla, CA.