Iron metabolism and preeclampsia: new insights from bioinformatics analysis.

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Published Date: Jul 1, 2025

Abstract

OBJECTIVE: Preeclampsia (PE) is a multifactorial systemic pregnancy disease, in which iron metabolism and ferroptosis play significant roles during its pathogenesis. The diagnosis and prevention of PE remain urgent clinical issues that need to be addressed. Therefore, finding molecular diagnostic targets for PE through bioinformatics and machine learning methods is crucial for the diagnosis and prevention of patients with PE.

Authors

  • Xijiao Guo
    Department of Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Sha Li
    School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China. u3003781@connect.hku.hk.
  • Guoping Xiong
    Obstetric, Centre Hospital of Wuhan, Huazhong University of Science and Technology, Wuhan, Hubei, 430014, People's Republic of China.

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