Biomanufacturing in low Earth orbit: A paradigm shift.

Journal: Stem cell reports
Published Date: Jun 19, 2025

Abstract

This perspective article explores the transformative potential of biomanufacturing in low Earth orbit (LEO) for regenerative medicine. Building on key symposia and workshops, it highlights the International Space Station (ISS) National Laboratory's role in advancing tissue engineering through microgravity research. The article discusses breakthroughs in stem cell therapies, disease modeling, and automation, while emphasizing the need for collaboration, investment, and emerging technologies like AI and machine learning. Insights from the scientific community and market analyses point to a rapidly growing sector. Strategic partnerships and policy support will be essential to scale space-based biomanufacturing and unlock new therapeutic possibilities for patients on Earth.

Authors

  • Davide Marotta
    International Space Station National Laboratory, Melbourne, Florida, USA. Electronic address: dmarotta@issnationallab.org.
  • Noor Ward
    International Space Station National Laboratory, Melbourne, Florida, USA.
  • Steven R Bauer
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Electronic address: steven.bauer@fda.hhs.gov.
  • Joshua Hunsberger
    Regenerative Medicine Manufacturing Society, Winston-Salem, North Carolina, USA.
  • Jana Stoudemire
    Axiom Space, Houston, Texas, USA.
  • Kenneth Savin
    Redwire Space, Jacksonville, Florida, USA.
  • Marc Giulianotti
    Sierra Space Corp., Louisville, Colorado, USA.
  • Catriona H M Jamieson
    UC San Diego Sanford Stem Cell Institute, La Jolla, California, USA.
  • Donna Roberts
    International Space Station National Laboratory, Melbourne, Florida, USA.
  • Michael Roberts
    EPSRC Centre for Mathematical Imaging in Healthcare, University of Cambridge, Cambridge, UK.

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