AIMC Topic: Tissue Engineering

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Hybrid additive manufacturing and data-guided design optimization for graded anterior cruciate ligament engineering.

Biomedical materials (Bristol, England)
Interface tissues, such as the enthesis connecting ligaments to bone, present multiphasic architectures with continuous gradients in structure, composition, and mechanics. Engineering such complex transitions remains a major challenge in biofabricati...

AI-powered printability evaluation framework for 3D bioprinting using Hausdorff distance metrics.

Biofabrication
3D bioprinting enables rapid fabrication of complex biological structures for tissue engineering applications. However, optimizing bioink formulation remains challenging due to complex relationships among material properties, printability, and cell v...

Artificial intelligence-enabled hydrogels: innovations and applications.

Journal of materials chemistry. B
Due to the excellent biocompatibility and adjustability, hydrogels have broadened their application in different fields, such as 3D printing, tissue engineering, drug delivery, and biosensing. However, traditional hydrogel research is confronted with...

Decellularized tumor matrices as biomimetic cancer niche: a new perspective on cancer research and therapy.

Biomedical materials (Bristol, England)
Cancer is among the major causes of mortality, responsible for approximately 15% of all deaths worldwide. Despite remarkable progress in modern medicine, it remains a significant global health challenge. Nevertheless, conventional therapies such as c...

Functionalized mesenchymal stem cells for enhanced bone regeneration: advances and challenges.

Stem cell research & therapy
Bone fracture continues to pose a significant clinical challenge in regenerative medicine due to limited repair capacity and inadequate therapeutic options. Among the various therapeutic strategies, mesenchymal stem cells have shown strong potential ...

Alginate-based 3D bioprinting strategies for structure-function integrated tissue regeneration.

Journal of materials chemistry. B
Alginate-based biomaterials have been widely used for tissue repair and regeneration, owing to their tunability, biocompatibility, biodegradability, and low cytotoxicity. With the rapid advancement of bioprinting technology, alginate has increasingly...

Recellularization of scaffolds derived from precision-cut kidney slices.

Biomedical materials (Bristol, England)
The global rise in chronic kidney disease necessitates innovative solutions for end-stage renal disease that can help to overcome the limitations of the only available treatment options, transplantation and dialysis. Tissue engineering presents a pro...

Utilizing cues from developmental neurogenesis and gliogenesis for better brain models.

Artificial cells, nanomedicine, and biotechnology
With a globally ageing population, neurodegenerative disease poses an increasingly greater risk to health span, yet there are still no curative treatments. Efficient biomimetic modelling is the underlying target for improving preclinical-to-clinical ...

Robotic micromanipulation for patterned and complex organoid biofabrication.

Science advances
Organoids have emerged as powerful models for recapitulating tissue physiology and pathology in biomedical research. However, the need for consistent and complex manufacturing of organoids remains a challenge. The absence of standardization and quali...

A detailed guide to melt electro-writing for tissue engineering applications.

Biofabrication
Melt electro-writing (MEW) is an advanced 3D printing technique with significant potential in tissue engineering due to its ability to create highly precise microscale structures using biocompatible materials. This review provides a comprehensive gui...