AIMC Topic: Tissue Engineering
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Computational optimization of 3D printed bone scaffolds using orthogonal array-driven FEA and neural network modeling.
Scientific reports
Aug 20, 2025
Today, orthopedic surgeons have been continuously focusing on bone tissue engineering for regenerating damaged bone through the use of biomimetic scaffolds and innovative materials. Hence, this study presents a comprehensive investigation into the op...
Computer vision to predict cell seeding coverage in re-endothelialized mouse lungs.
Scientific reports
Jul 19, 2025
Transplantation of donor grafts recellularized with recipient-derived or non-immunogenic universal cells is a potential means of reducing the graft rejection and post-transplant complications in lung transplantation. Achieving a fully recellularized ...
Decoding tissue complexity: multiscale mapping of chemistry-structure-function relationships through advanced visualization technologies.
Journal of materials chemistry. B
Jul 10, 2025
Comprehensively acquiring biological tissue information is pivotal for advancing our understanding of biological systems, elucidating disease mechanisms, and developing innovative clinical strategies. Biological tissues, as nature's archetypal biomat...
Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment.
Nature communications
Jul 4, 2025
Current approaches for bone repair predominantly target localized delivery of growth factors that are aimed at the coupling of angiogenesis and osteogenesis. However, delayed revascularization and regeneration of critical-sized bone defects are still...
Discovering novel type I collagen fragments from Cyprinus carpio supporting bone regeneration.
Functional & integrative genomics
Jul 4, 2025
Fish collagen is gaining increasing attention in tissue engineering due to its exceptional bioactivity. This study aimed to isolate functional fish collagen fragments capable of microbial biosynthesis and supporting bone tissue regeneration. Collagen...
Biomanufacturing in low Earth orbit: A paradigm shift.
Stem cell reports
Jun 19, 2025
This perspective article explores the transformative potential of biomanufacturing in low Earth orbit (LEO) for regenerative medicine. Building on key symposia and workshops, it highlights the International Space Station (ISS) National Laboratory's r...
A soft robotic total artificial hybrid heart.
Nature communications
Jun 3, 2025
End-stage heart failure is a deadly disease. Current total artificial hearts (TAHs) carry high mortality and morbidity and offer low quality of life. To overcome current biocompatibility issues, we propose the concept of a soft robotic, hybrid (pumpi...
Measuring alignment of structural proteins in engineered tissue constructs using polarized Raman spectroscopy.
PloS one
May 30, 2025
Measures of structural protein alignment within biological and engineered tissues are needed for improved understanding of their mechanical behavior and functionality. We advance our method of measuring protein alignment using polarized Raman spectro...
Optimal structural characteristics of osteoinductivity in bioceramics derived from a novel high-throughput screening plus machine learning approach.
Biomaterials
Apr 16, 2025
Osteoinduction is an important feature of the next generation of bone repair materials. But the key structural factors and parameters of osteoinductive scaffolds are not yet clarified. This study leverages the efficiency of high-throughput screening ...
Surrogate modeling of electrospun PVA/PLA nanofibers using artificial neural network for biomedical applications.
Scientific reports
Apr 15, 2025
Blending poly (lactic acid) (PLA) with poly (vinyl alcohol) (PVA) improves the strength and hydrophilicity of nanofibers, making them suitable for biomedical applications like wound dressings. This study explores how electrospinning parameters-applie...
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