Omics in IgG4-related disease.

Journal: Chinese medical journal
Published Date: Oct 25, 2024

Abstract

Research on IgG4-related disease (IgG4-RD), an autoimmune condition recognized to be a unique disease entity only two decades ago, has processed from describing patients' symptoms and signs to summarizing its critical pathological features, and further to investigating key pathogenic mechanisms. Challenges in gaining a better understanding of the disease, however, stem from its relative rarity-potentially attributed to underrecognition-and the absence of ideal experimental animal models. Recently, with the development of various high-throughput techniques, "omics" studies at different levels (particularly the single-cell omics) have shown promise in providing detailed molecular features of IgG4-RD. While, the application of omics approaches in IgG4-RD is still at an early stage. In this paper, we review the current progress of omics research in IgG4-RD and discuss the value of machine learning methods in analyzing the data with high dimensionality.

Authors

  • Shaozhe Cai
    Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Yu Chen
    State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
  • Ziwei Hu
    Institute of Pharmaceutical Analysis , College of Pharmacy , Jinan University , Guangzhou , Guangdong 510632 , China . Email: haibo.zhou@jnu.edu.cn ; Email: jzjjackson@hotmail.com ; Email: tghao@jnu.edu.cn.
  • Shengyan Lin
    Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Rongfen Gao
    Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Bingxia Ming
    Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Jixin Zhong
    Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Wei Sun
    Sutra Medical Inc, Lake Forest, CA.
  • Qian Chen
    Department of Pain Medicine Guizhou Provincial Orthopedics Hospital Guiyang Guizhou China.
  • John H Stone
    Division of Rheumatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02301, USA.
  • Lingli Dong
    Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

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