Journal of computer-aided molecular design
Oct 24, 2025
The interaction between staphylococcal protein A (SpA) and human immunoglobulin G (IgG) is pivotal in treating diseases such as cancer, inflammation, infections, and autoimmune disorders. However, acquiring natural SpA variants is labor-intensive, tr...
Experimental screening for biopharmaceutical developability properties typically relies on resource-intensive, and time-consuming assays such as size exclusion chromatography (SEC). This study highlights the potential of in silico models to accelerat...
N. Nair, A. Marques , E. J. Horn, G. Brown et al., J Clin Microbiol 63:e0034725, 2025, https://doi.org/10.1128/jcm.00347-25 present data to demonstrate that infection by , the primary causative agent of Lyme disease in the USA, leads to immunoglobuli...
A key issue in the post-COVID-19 pandemic era is the ongoing administration of COVID-19 vaccines. Repeated vaccination is essential for preparing against currently circulating and newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-C...
BACKGROUND AND OBJECTIVES: Although disease-modifying therapies (DMTs) may suppress coronavirus disease 2019 (COVID-19) vaccine responses in people with multiple sclerosis (pwMS), limited data are available on the cumulative effect of additional boos...
Ebola virus disease (EVD) outbreaks are increasing, posing significant threats to affected communities. Effective outbreak management depends on protecting frontline health workers, a key focus of EVD vaccination strategies. IgG specific to the viral...
OBJECTIVE: This study aimed to perform a detailed stratification analysis of B lymphocyte subsets in patients with primary Sjögren's syndrome (pSS) and to investigate their associations with lymphoma risk, clinical phenotypes, and disease activity.
BACKGROUND: Latin America has been experiencing an Oropouche virus (OROV) outbreak of unprecedented magnitude and spread since 2023-24 for unknown reasons. We aimed to identify risk predictors of and areas at risk for OROV transmission.
Native ion mobility-mass spectrometry combined with collision-induced unfolding (CIU) is a powerful analytical method for protein characterization, offering insights into structural stability and enabling the differentiation of analytes with similar ...
The integration of paper-based microfluidics with deep learning represents a pivotal trend in enhancing diagnostic capabilities. This paper introduces a new approach to improve the performance of a paper-based microfluidic enzyme-linked immunosorbent...
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