Production of bioactive peptides by high-voltage pulsed electric field: Protein extraction, mechanism, research status and collaborative application.

Journal: Food chemistry
Published Date: Apr 1, 2025

Abstract

Bioactive peptides exhibit a variety of potential applications in the fields of medicine, food and cosmetics. However, studies have shown that the traditional preparation is characterized by low efficiency, substantial pollution, limited activities and poor purity, which constrains their further application. High-voltage pulsed electric field (HPEF) technology, as a physical non-thermal processing method, shows unique advantages in bioactive peptide preparation. Through comprehensive analysis, this paper reveals the main principle of HPEF technology, the extraction of proteins (break up cellular tissue), the structural changes of proteins, enzymes and bioactive peptides after treatment, the improvement of bioactive peptides' functional properties and the potential in promoting bioactive peptides' large-scale production. Besides, this paper introduces the application of other non-thermal processing technologies, artificial intelligence and nanotechnology, providing new ways of thinking for the efficient preparation and application of bioactive peptides and establishes a theoretical foundation for the application and promotion of HPEF technology.

Authors

  • Zeyuan Kang
    State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang 315211, China; Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Zhejiang Key Laboratory of Food Microbiology and Nutritional Health, College of Food Science and Engineering, Ningbo University, Ningbo 315800, China.
  • Zhicheng Wang
    Department of Neurosurgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
  • Jingjing Wang
    Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, China; School of Medicine, South China University of Technology, Guangzhou, Guangdong Province, China.
  • Qirui Liu
    State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang 315211, China; Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Zhejiang Key Laboratory of Food Microbiology and Nutritional Health, College of Food Science and Engineering, Ningbo University, Ningbo 315800, China.
  • Daodong Pan
    State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang 315211, China; Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Zhejiang Key Laboratory of Food Microbiology and Nutritional Health, College of Food Science and Engineering, Ningbo University, Ningbo 315800, China.
  • Zhen Wu
    Department of Neurosurgery/China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, China.
  • Xiaoqun Zeng
    State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang 315211, China; Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Zhejiang Key Laboratory of Food Microbiology and Nutritional Health, College of Food Science and Engineering, Ningbo University, Ningbo 315800, China.
  • Maolin Tu
    State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang 315211, China; Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, Zhejiang Key Laboratory of Food Microbiology and Nutritional Health, College of Food Science and Engineering, Ningbo University, Ningbo 315800, China. Electronic address: tumaolin012@163.com.

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