Chemical communications (Cambridge, England)
Jan 13, 2026
Peptide-based therapeutics have emerged as a significant treatment strategy, offering high specificity and tunable pharmacokinetics. Recent advances in Artificial Intelligence (AI) have shifted the focus towards structure prediction, generative desig...
Journal of computer-aided molecular design
Jan 12, 2026
The integration of artificial intelligence (AI) with molecular modeling offers new opportunities to accelerate therapeutic discovery. In this study, we developed an AI-driven generative pipeline combining deep reinforcement learning (DRL), generative...
Proteases, enzymes that play critical roles in health and disease, exert their function through the cleavage of peptide bonds. Identifying substrates that are efficiently and selectively cleaved by target proteases is essential for studying protease ...
BACKGROUND: For most species, Aging is an inevitable biological process that poses significant challenges to global healthcare due to age-related diseases. Recent advances in peptide therapy have highlighted anti-aging peptides (AAPs) as a promising ...
Journal of the American Society for Mass Spectrometry
Dec 21, 2025
Recent advances in ion mobility spectrometry have enabled the measurement of rotationally averaged collisional cross-sectional area (CCS) for millions of peptides as part of routine proteomic mass spectrometry workflows. One of the most striking find...
Endometrial cancer (EC) molecular subtyping is critical for prognosis and treatment but remains hindered by reliance on invasive tissue biopsies and time-consuming genomic sequencing. Here, we present a minimally invasive approach integrating MALDI-T...
Journal of the American Society for Mass Spectrometry
Nov 27, 2025
Proteogenomics integrates genomics and mass spectrometry (MS) data to understand complex biological systems, disease mechanisms, and potential biomarkers. However, the high volume and noise in MS data present computational and interpretational challe...
World journal of microbiology & biotechnology
Nov 18, 2025
There is a growing concern about fungal infections and antifungal resistance among fungal species, underscoring the need for finding alternative treatments. Antifungal peptides (AFPs) are interesting and promising candidates for developing novel anti...
European journal of medicinal chemistry
Nov 16, 2025
The chimera combining the peptide nucleic acids (PNAs) and peptides represent a promising bifunctional strategy by concurrently binding with protein catalytic pocket and its associated RNA template, effectively disrupting protein's function. Conventi...
Data-independent acquisition (DIA)-based mass spectrometry is becoming an increasingly popular mass spectrometry acquisition strategy for carrying out quantitative proteomics experiments. Most of the popular DIA search engines make use of in silico g...
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