Evaluating ChatGPT's Utility in Biologic Therapy for Systemic Lupus Erythematosus: Comparative Study of ChatGPT and Google Web Search.

Journal: JMIR formative research
Published Date: Aug 28, 2025

Abstract

BACKGROUND: Systemic lupus erythematosus (SLE) is a life-threatening, multisystem autoimmune disease. Biologic therapy is a promising treatment for SLE. However, public understanding of this therapy is still insufficient, and the quality of related information on the internet varies, which affects patients' acceptance of this treatment. The effectiveness of artificial intelligence technologies, such as ChatGPT (OpenAI), in knowledge dissemination within the health care field has attracted significant attention. Research on ChatGPT's utility in answering questions regarding biologic therapy for SLE could promote the dissemination of this treatment.

Authors

  • Kai Li
    Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
  • Yunfei Peng
    School of Journalism and Communication, Guangxi University, No.100, Daxue East Road, Nanning, 530004, China, 86 13367611322.
  • Luyi Li
    School of Journalism and Communication, Guangxi University, No.100, Daxue East Road, Nanning, 530004, China, 86 13367611322.
  • Bo Liu
    Wuhan United Imaging Healthcare Surgical Technology Co., Ltd., Wuhan, China.
  • Zhijian Huang
    School of Computer Science and Engineering, Central South University, 410075, Changsha, China.

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