Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells.

Journal: Frontiers in immunology
PMID: 39723207

Abstract

BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. These receptors are targeted in autoimmune-induced thyroid eye disease (TED). Effective therapeutic treatment of TED inhibits activation of the IGF-1R/TSH-R complex.

Authors

  • Maximilian Luffy
    Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg-University (JGU) Medical Center, Mainz, Germany.
  • Anna-Lena Ganz
    Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg-University (JGU) Medical Center, Mainz, Germany.
  • Stefanie Wagner
    Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg-University (JGU) Medical Center, Mainz, Germany.
  • Jan Wolf
    Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg-University (JGU) Medical Center, Mainz, Germany.
  • Julian Ropertz
    Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg-University (JGU) Medical Center, Mainz, Germany.
  • Ryan Zeidan
    Sling Therapeutics, Ann Arbor, MI, United States.
  • Jeffrey D Kent
    Sling Therapeutics, Ann Arbor, MI, United States.
  • Raymond S Douglas
    Sling Therapeutics, Ann Arbor, MI, United States.
  • George J Kahaly
    Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg-University (JGU) Medical Center, Mainz, Germany.

Keywords

External Resources

Popular Topics
Recent Journals