AIMC Topic: Apoptosis
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Machine learning based screening of biomarkers associated with cell death and immunosuppression of multiple life stages sepsis populations.
Scientific reports
Aug 19, 2025
Sepsis is a condition resulting from the uncontrolled immune response to infection, leading to widespread inflammatory damage and potentially fatal organ dysfunction. Currently, there is a lack of specific prevention and treatment strategies for seps...
Identification and experimental validation of BMX as a crucial PANoptosis‑related gene for immune response in Spinal Cord Injury.
PloS one
Jul 15, 2025
Spinal cord injury (SCI) is a debilitating neurological condition that severely impacts motor, sensory, and autonomic functions, leading to significant challenges in patient quality of life and imposing substantial economic burdens on society. PANopt...
Integrative Role of RNA N7-methylguanosine in epilepsy: Regulation of neuronal oxidative phosphorylation, programmed death and immune microenvironment.
PloS one
Jul 14, 2025
Epilepsy is a common brain disease that causes different types of seizures, with an incidence rate of nearly 1%. N7-methylguanosine (m7G) is a prevalent RNA modification that has attracted significant attention in recent research. In this study, we i...
Machine-Learning-Driven Discovery of -Phenylbenzenesulfonamides as a Novel Chemotype for Lactate Dehydrogenase A Inhibition with Anti-Pancreatic Cancer Activity.
Journal of medicinal chemistry
Jul 11, 2025
Lactate dehydrogenase A (LDHA) is a promising target for cancer therapy due to its crucial role in aerobic glycolysis. Despite extensive efforts, the structural diversity of LDHA inhibitors remains limited. Here, we utilized machine learning techniqu...
Identification and validation of glucocorticoid receptor and programmed cell death-related genes in spinal cord injury using machine learning.
Scientific reports
Jul 7, 2025
Spinal cord injury (SCI) is a severe neurological disorder, with glucocorticoids like methylprednisolone commonly used for treatment. However, their efficacy and risks remain controversial. Programmed cell death (PCD) mechanisms have been increasingl...
Deep learning-driven drug response prediction and mechanistic insights in cancer genomics.
Scientific reports
Jul 1, 2025
In the field of cancer therapy, the diversity and heterogeneity of cancer genomes in clinical patients complicate and challenge the effective use of non-targeted drugs, as these drugs often fail to address specific genetic events. Recent advancements...
Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males.
Science translational medicine
May 28, 2025
Severe injury accompanied by hemorrhagic shock triggers an early release of cell constituents into the circulation, referred to as the systemic storm. The systemic storm drives the systemic inflammatory response and is associated with increased morta...
The Role of Hydrogen Sulfide in the Localization and Structural-Functional Organization of p53 Following Traumatic Brain Injury: Development of a YOLO Model for Detection and Quantification of Apoptotic Nuclei.
International journal of molecular sciences
May 24, 2025
Traumatic brain injury (TBI) triggers a cascade of molecular and cellular disturbances, including apoptosis, inflammation, and destabilization of neuronal connections. The transcription factor p53 plays a pivotal role in regulating cell fate followin...
Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia.
Journal of translational medicine
May 21, 2025
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...
A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties.
BMC cancer
May 12, 2025
Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cancer cell types. We synthesized optimized niosome NPs (NPs) with high solubility and capacity for solanin...
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