AIMC Topic: Receptor, IGF Type 1

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Epistasis regulates genetic control of cardiac hypertrophy.

Nature cardiovascular research Jun 5, 2025
Although genetic variant effects often interact nonadditively, strategies to uncover epistasis remain in their infancy. Here we develop low-signal signed iterative random forests to elucidate the complex genetic architecture of cardiac hypertrophy, u...
Phenotype Female Humans Ventricular Remodeling Myocytes, Cardiac Receptor, IGF Type 1 Heart Failure Induced Pluripotent Stem Cells Connectin Hypertrophy, Left Ventricular Genome-Wide Association Study Epistasis, Genetic Gene Regulatory Networks Middle Aged Genetic Predisposition to Disease Aged Magnetic Resonance Imaging Deep Learning Male
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Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells.

Frontiers in immunology Dec 11, 2024
BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) and the thyrotropin receptor (TSH-R) are expressed on orbital cells and thyrocytes. These receptors are targeted in autoimmune-induced thyroid eye disease (TED). Effective therapeutic tre...
Pyrazines Antibodies, Monoclonal Cricetulus Imidazoles Antibodies, Monoclonal, Humanized Apoptosis Phosphorylation Receptor, IGF Type 1 CHO Cells Animals Cell Proliferation Humans
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Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival.

Journal of the American Heart Association Oct 16, 2019
Background Small molecule kinase inhibitors (KIs) are a class of agents currently used for treatment of various cancers. Unfortunately, treatment of cancer patients with some of the KIs is associated with cardiotoxicity, and there is an unmet need fo...
Myocytes, Cardiac Protein Kinase Inhibitors TOR Serine-Threonine Kinases Adenosine Triphosphate Cardiotoxins Rats Cell Survival Receptor, IGF Type 1 Phosphatidylinositol 3-Kinases Cells, Cultured Animals Machine Learning
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Artificial Intelligence Approach To Investigate the Longevity Drug.

The journal of physical chemistry letters Aug 14, 2019
Longevity is a very important and interesting topic, and has been demonstrated to be related to longevity. We combined network pharmacology, machine learning, deep learning, and molecular dynamics (MD) simulation to investigate potent lead drugs. Re...
Protein Binding Signal Transduction Medicine, Chinese Traditional Klotho Proteins Drug Discovery Protein Interaction Maps Molecular Docking Simulation Inhibitory Concentration 50 Binding Sites Thermodynamics Receptor, Insulin Antigens, CD Ligands Glucuronidase Receptor, IGF Type 1 Algorithms Databases, Factual Artificial Intelligence
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