Identifying DNA-binding proteins by combining support vector machine and PSSM distance transformation.
Journal:
BMC systems biology
Published Date:
Feb 6, 2015
Abstract
BACKGROUND: DNA-binding proteins play a pivotal role in various intra- and extra-cellular activities ranging from DNA replication to gene expression control. Identification of DNA-binding proteins is one of the major challenges in the field of genome annotation. There have been several computational methods proposed in the literature to deal with the DNA-binding protein identification. However, most of them can't provide an invaluable knowledge base for our understanding of DNA-protein interactions.