Comparison of dengue, chikungunya, and Zika among children in Nicaragua across 18 years: a single-centre, prospective cohort study.

Journal: The Lancet. Child & adolescent health
Published Date: Sep 1, 2025

Abstract

BACKGROUND: Dengue, chikungunya, and Zika are diseases of major human concern. Differential diagnosis of these three diseases is complicated in children and adolescents due to overlapping clinical features (signs, symptoms, and complete blood count results). Few studies have directly compared these three diseases. We aimed to use 18 years of primary care observations from a paediatric cohort to characterise the distinguishing features of dengue, chikungunya, and Zika.

Authors

  • Fausto Andres Bustos Carrillo
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA; Division of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
  • Sergio Ojeda
    Sustainable Sciences Institute, Managua, Nicaragua.
  • Nery Sanchez
    Sustainable Sciences Institute, Managua, Nicaragua.
  • Miguel Plazaola
    Sustainable Sciences Institute, Managua, Nicaragua.
  • Damaris Collado
    Sustainable Sciences Institute, Managua, Nicaragua.
  • Tatiana Miranda
    Sustainable Sciences Institute, Managua, Nicaragua.
  • Saira Saborio
    Sustainable Sciences Institute, Managua, Nicaragua.
  • Brenda Lopez Mercado
    Sustainable Sciences Institute, Managua, Nicaragua.
  • Jairo Carey Monterrey
    Sustainable Sciences Institute, Managua, Nicaragua.
  • Sonia Arguello
    Sustainable Sciences Institute, Managua, Nicaragua.
  • Lora Campredon
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
  • Zijin Chu
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
  • Colin J Carlson
    Department of Epidemiology of Microbial Diseases, Yale University School of Public Health, New Haven, CT, USA.
  • Aubree Gordon
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
  • Angel Balmaseda
    Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua.
  • Guillermina Kuan
    Centro de Salud Sócrates Flores Vivas, Ministry of Health, Managua, Nicaragua.
  • Eva Harris
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, 94720-3370, USA.

Keywords

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