Ontology accelerates few-shot learning capability of large language model: A study in extraction of drug efficacy in a rare pediatric epilepsy.

Journal: International journal of medical informatics
Published Date:

Abstract

OBJECTIVE: Dravet Syndrome (DS) is a developmental and epileptic encephalopathy that is characterized by severe, prolonged motor seizures and high resistance to multiple antiseizure medications (ASMs) with multiple comorbidities. Evaluating the efficacy of new drugs in DS preclinical models and mapping them to human phenotypes of DS through analysis of published literature is an important goal for improving outcomes in this rare pediatric epilepsy.

Authors

  • Pedram Golnari
    Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Katrina Prantzalos
    Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
  • Veronica Hood
    Dravet Syndrome Foundation, Inc, PO Box 3026, Cherry Hill, NJ 08034, USA.
  • Mary Anne Meskis
    Dravet Syndrome Foundation, Inc, PO Box 3026, Cherry Hill, NJ 08034, USA.
  • Lori L Isom
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-5632, USA.
  • Karen Wilcox
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
  • Jack M Parent
    Department of Neurology and Michigan Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Dennis Lal
    Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Neurogenetics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and M.I.T., Cambridge, MA 02142, USA.
  • Samden D Lhatoo
    University of Texas Health Science Center at Houston, Houston, TX 77030.
  • Howard P Goodkin
    Department of Neurology and Pediatrics, University of Virginia, Charlottesville VA 22903, USA.
  • Elaine C Wirrell
    Divisions of Child & Adolescent Neurology and Epilepsy, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
  • Kelly G Knupp
    Department of Pediatrics and Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Manisha Patel
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO 80045, USA.
  • Jeffrey A Loeb
    Department of Neurology and Rehabilitation, University of Illinois Chicago, Chicago, IL 60612, USA.
  • Joseph E Sullivan
    Departments of Neurology and Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Lauren Harte-Hargrove
    CURE Epilepsy, Chicago, IL 60611, USA.
  • Brandy E Fureman
    Epilepsy Foundation, 3540 Crain Highway, Suite 675, Bowie, MD 20716, USA.
  • Jeffrey Buchhalter
    Department of Neurology, St Joseph's Hospital and Medical Center, Phoenix, Arizona.
  • Satya S Sahoo
    Division of Medical Informatics, School of Medicine, Case Western Reserve University, Cleveland, OH.