Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management.

Journal: Drug design, development and therapy

PMID: 39722678

Abstract

PURPOSE: Nitrofurantoin (NITRO), a long-standing antibiotic to treat urinary tract infections, is activated by Nitro reductases. This activation mechanism has led to its exploration for repositioning applications in controlling and treating breast cancer, which express a Nitro reductase gene.

Authors

Dina Louis

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Christianne Mounir Zaki Rizkalla

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Amira Rashad

Department of Pharmaceutical Technology, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.

Keywords

Breast Neoplasms Cell Proliferation Cell Survival Dose-Response Relationship, Drug Drug Delivery Systems Drug Repositioning Drug Screening Assays, Antitumor Female Humans MCF-7 Cells Nitrofurantoin Particle Size Structure-Activity Relationship

External Resources

View on PubMed Access via DOI PubMed (39722678)

Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management.

Abstract

Authors

Keywords

External Resources

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