Prediction of feature genes in trauma patients with the TNF rs1800629 A allele using support vector machine.

Journal: Computers in biology and medicine
Published Date:

Abstract

BACKGROUND: Tumor necrosis factor (TNF)-α variant is closely linked to sepsis syndrome and mortality after severe trauma. We aimed to identify feature genes associated with the TNF rs1800629 A allele in trauma patients and help to direct them toward alternative successful treatment.

Authors

  • Guoting Chen
    Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, No. 150, Jimo Road, Shanghai 200120, China.
  • Ning Han
    State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China; College of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China; Key Laboratory of Science and Technology on Particle Materials, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 361021, China. Electronic address: nhan@ipe.ac.cn.
  • Guofeng Li
    Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, No. 150, Jimo Road, Shanghai 200120, China.
  • Xin Li
    Veterinary Diagnostic Center, Shanghai Animal Disease Control Center, Shanghai, China.
  • Guang Li
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
  • Yangzhou Liu
    Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, No. 150, Jimo Road, Shanghai 200120, China.
  • Wei Wu
    Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Yong Wang
    State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hunghom Kowloon Hong Kong P. R. China kwok-yin.wong@polyu.edu.hk.
  • Yanxi Chen
    Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, No. 150, Jimo Road, Shanghai 200120, China.
  • Guixin Sun
    Department of Traumatic Surgery, Shanghai East Hospital, Nanjing Medical University, Nanjing, China.
  • Zengchun Li
    Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, No. 150, Jimo Road, Shanghai 200120, China.
  • Qinchuan Li
    Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, No. 150, Jimo Road, Shanghai 200120, China. Electronic address: qinchuan_li@163.com.