AIMC Topic: Ribosomal Proteins

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Machine learning-based proteomics profiling of ALS identifies downregulation of RPS29 that maintains protein homeostasis and STMN2 level.

Communications biology Aug 7, 2025
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease. The molecular understanding of ALS is hampered by the lack of experimental models recapitulating disease heterogeneity and analytical framework integrating multi-omics dataset...
Humans Machine Learning Biomarkers Animals Proteomics Amyotrophic Lateral Sclerosis Down-Regulation Motor Neurons Ribosomal Proteins Proteostasis
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AI based natural inhibitor targeting RPS20 for colorectal cancer treatment using integrated computational approaches.

Scientific reports Jul 10, 2025
The increasing global incidence of cancer emphasizes the vital role of machine learning algorithms and artificial intelligence (AI) in identifying novel anticancer targets and developing new drugs. Computational approaches can significantly quicken r...
Humans Artificial Intelligence Machine Learning Colorectal Neoplasms Molecular Docking Simulation Antineoplastic Agents Molecular Dynamics Simulation Indoles Binding Sites Ribosomal Proteins
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Rama: a machine learning approach for ribosomal protein prediction in plants.

Scientific reports Nov 24, 2017
Ribosomal proteins (RPs) play a fundamental role within all type of cells, as they are major components of ribosomes, which are essential for translation of mRNAs. Furthermore, these proteins are involved in various physiological and pathological pro...
Machine Learning RNA-Binding Proteins Plant Proteins Ribosomal Proteins
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Prediction of feature genes in trauma patients with the TNF rs1800629 A allele using support vector machine.

Computers in biology and medicine Jun 9, 2015
BACKGROUND: Tumor necrosis factor (TNF)-α variant is closely linked to sepsis syndrome and mortality after severe trauma. We aimed to identify feature genes associated with the TNF rs1800629 A allele in trauma patients and help to direct them toward ...
Humans Tumor Necrosis Factor-alpha Gene Expression Profiling Support Vector Machine Alleles Heme Oxygenase-1 Wounds and Injuries Ribosomal Proteins
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