Simulation Experiment Description Markup Language (SED-ML) Level 1 Version 2.

Journal: Journal of integrative bioinformatics
Published Date:

Abstract

The number, size and complexity of computational models of biological systems are growing at an ever increasing pace. It is imperative to build on existing studies by reusing and adapting existing models and parts thereof. The description of the structure of models is not sufficient to enable the reproduction of simulation results. One also needs to describe the procedures the models are subjected to, as recommended by the Minimum Information About a Simulation Experiment (MIASE) guidelines. This document presents Level 1 Version 2 of the Simulation Experiment Description Markup Language (SED-ML), a computer-readable format for encoding simulation and analysis experiments to apply to computational models. SED-ML files are encoded in the Extensible Markup Language (XML) and can be used in conjunction with any XML-based model encoding format, such as CellML or SBML. A SED-ML file includes details of which models to use, how to modify them prior to executing a simulation, which simulation and analysis procedures to apply, which results to extract and how to present them. Level 1 Version 2 extends the format by allowing the encoding of repeated and chained procedures.

Authors

  • Frank T Bergmann
    BioQUANT/COS, Heidelberg University, Heidelberg, Germany.
  • Jonathan Cooper
  • Nicolas Le Novère
  • David Nickerson
    Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
  • Dagmar Waltemath
    Department of Medical Informatics, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.