Agent-based modeling (ABM) is a powerful computational approach for studying complex biological and biomedical systems, yet its widespread use remains limited by significant computational demands. As models become increasingly sophisticated, the numb...
BACKGROUND: Quantitative kinetic models of biological regulatory processes play an important role in understanding disease mechanisms. However, their simulation and analysis require specialized domain expertise.
Bovine respiratory disease (BRD) is a multifactorial disease of dairy and beef cattle that involves complex interactions with the host immune system. In the current study, a comprehensive meta-analysis was performed using a P-value combination approa...
Honey bees () are vital pollinators essential for maintaining ecosystem stability and global food production, but they face escalating threats from pathogens, agrochemicals, and climate change. Although proteomics has advanced our understanding of be...
Preeclampsia (PE), a devastating pregnancy complication affecting 5% of gravidas worldwide, exhibits poorly characterized connections between mitochondrial dysfunction and immune dysregulation. This study aims to identify integrated mitochondrial-imm...
Universal differential equations (UDEs) are an emerging approach in biomedical systems biology, integrating physiology-driven mathematical models with machine learning for data-driven model discovery in areas where knowledge of the underlying physiol...
The escalating global environmental crisis demands transformative biotechnological solutions that are both sustainable and scalable. This perspective advocates Data-Driven Synthetic Microbes (DDSM); engineered microorganisms designed through integrat...
Use of highly purified antigens to improve vaccine safety has led to reduced immunogenicity and efficacy, resulting in the need for adjuvants to increase and/or modulate the immunogenicity of the vaccine. Despite the need for potent and safe vaccine ...
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
May 8, 2025
Since the turn of the millennium, computational modelling of biological systems has evolved remarkably and sees matured use spanning basic and clinical research. While the topic of the peri-millennial debate about the virtues and limitations of 'redu...
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